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KMID : 1103920130190010045
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Korean Journal of Hepatology
2013 Volume.19 No. 1 p.45 ~ p.50
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Clinical and epidemiological characteristics of Korean patients with hepatitis C virus genotype 6
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Seong Mun-Hyuk
Kil Ho
Kim Jong-Yeop
Lee Sang-Soo
Jang Eun-Sun
Kim Jin-Wook
Jeong Sook-Hyang
Kim Young-Seok
Bae Si-Hyun
Lee Youn-Jae
Lee Han-Chu
Yun Hae-Sun
Kang Byung-Hak
Kim Ki-Sang
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Abstract
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Background/Aims: The distribution of hepatitis C virus (HCV) genotypes varies geographically. In Korea, genotypes 1 and 2 comprise more than 90% of HCV infections, while genotype 6 is very rare. This study compared the clinical and epidemiological characteristics of patients with genotype 6 HCV infection with those infected with HCV genotypes 1 and 2.
Methods: This was a prospective, multicenter HCV cohort study that enrolled 1,173 adult patients, of which 930 underwent HCV genotype analysis, and only 9 (1.0%) were found to be infected with genotype 6 HCV. The clinical and epidemiological parameters of the genotypes were compared.
Results: The patients with genotype 6 HCV had a mean age of 41.5 years, 77.8% were male, and they had no distinct laboratory features. A sustained virologic response (SVR) was observed in four (67%) of six patients who received antiviral therapy. Risk factors such as the presence of a tattoo (n=6, 66.7%), more than three sexual partners (n=3, 33.3%), and injection drug use (n=3, 33.3%) were more common among genotype 6 patients than among genotypes 1 or 2.
Conclusions: The epidemiology and treatment response of patients infected with genotype 6 HCV differed significantly from those with genotypes 1 or 2, warranting continuous monitoring.
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KEYWORD
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HCV, Genotype, Epidemiology, Treatment, Korea
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